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Article

The CCN family member Wisp3, mutant in progressive pseudorheumatoid dysplasia, modulates BMP and Wnt signaling.

The Journal of clinical investigation - 1 Oct 2007

Nakamura Yukio, Weidinger Gilbert, Liang Jennifer O, Aquilina-Beck Allisan, Tamai Keiko, Moon Randall T, Warman Matthew L

Abstract excerpt

In humans, loss-of-function mutations in the gene encoding Wnt1 inducible signaling pathway protein 3 (WISP3) cause the autosomal-recessive skeletal disorder progressive pseudorheumatoid dysplasia (PPD). However, in mice there is no apparent phenotype caused by Wisp3 deficiency or overexpression....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 17823661
DOI: 10.1172/JCI32001
PMCID: PMC1964511

Genes

LRP6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17823661-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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The CCN family member Wisp3, mutant in progressive pseudorheumatoid dysplasia, modulates BMP and Wnt signaling.PMID 17823661Read ↗

WISP3, the gene responsible for the human skeletal disease progressive pseudorheumatoid dysplasia, is not essential for skeletal function in mice.Semantic proximity Read ↗

Mutations in the CCN gene family member WISP3 cause progressive pseudorheumatoid dysplasia.Semantic proximity Read ↗

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