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Article

Effect of O antigen glycosyl isomerase gene mutation on biological property and pathogenicity of Burkholderia pseudomallei strain BPC006.

International journal of biological macromolecules - 1 Feb 2024

Li Xiao, Wang Shiwei, Wu Pan, Nan Dongqi, Chen Dan, Suo Liangpeng, Lu Xiaoxue, Rao Chenglong, Li Qian, Yue Juanjuan, Xiang Yang, Mao Xuhu, Yan Jingmin

Abstract excerpt

Burkholderia pseudomallei, an intracellular pathogen, is responsible for melioidosis, a zoonotic disease. Its pathogenesis involves several virulence factors, among which lipopolysaccharide (LPS) plays a crucial role. Our research reveals that the O antigen present within the LPS significantly regulates the host immune response. In a previous study, we obtained a B. pseudomallei mutant strain ΔwbiI. Here, the...

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PMID: 38141699
DOI: 10.1016/j.ijbiomac.2023.128922

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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