Article
CD4+ T cell epitopes of FliC conserved between strains of Burkholderia: implications for vaccines against melioidosis and cepacia complex in cystic fibrosis.
Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2014
Musson Julie A, Reynolds Catherine J, Rinchai Darawan, Nithichanon Arnone, Khaenam Prasong, Favry Emmanuel, Spink Natasha, Chu Karen K Y, De Soyza Anthony, Bancroft Gregory J, Lertmemongkolchai Ganjana, Maillere Bernard, Boyton Rosemary J, Altmann Daniel M, Robinson John H
Abstract excerpt
Burkholderia pseudomallei is the causative agent of melioidosis characterized by pneumonia and fatal septicemia and prevalent in Southeast Asia. Related Burkholderia species are strong risk factors of mortality in cystic fibrosis (CF). The B. pseudomallei flagellar protein FliC is strongly seroreactive and vaccination protects challenged mice. We assessed B. pseudomallei FliC peptide binding affinity to multiple...
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