Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Thrombomodulin contributes to gamma tocotrienol-mediated lethality protection and hematopoietic cell recovery in irradiated mice.

PloS one - 1 Jan 2015

Pathak Rupak, Shao Lijian, Ghosh Sanchita P, Zhou Daohong, Boerma Marjan, Weiler Hartmut, Hauer-Jensen Martin

Abstract excerpt

Systemic administration of recombinant thrombomodulin (TM) confers radiation protection partly by accelerating hematopoietic recovery. The uniquely potent radioprotector gamma tocotrienol (GT3), in addition to being a strong antioxidant, inhibits the enzyme hydroxy-methyl-glutaryl-coenzyme A redu...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Cells
Share to Cytokines
Share to Endothelium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hematopoiesis

Share to Mice, Knockout

Share to Models, Animal

Share to Thrombomodulin

Share to Whole-Body Irradiation

Source

Open in PubMed Open full text

Identifiers

PMID: 25860286
DOI: 10.1371/journal.pone.0122511
PMCID: PMC4393275

Genes

HMGCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25860286-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Thrombomodulin contributes to gamma tocotrienol-mediated lethality protection and hematopoietic cell recovery in irradiated mice.PMID 25860286Read ↗

Thrombopoietin mimetic stimulates bone marrow vascular and stromal niches to mitigate acute radiation syndromeSemantic proximity Read ↗

The Protective Effects of 5-Methoxytryptamine-α-lipoic Acid on Ionizing Radiation-Induced Hematopoietic InjurySemantic proximity Read ↗

Thrombomodulin protects endothelial cells from a calcineurin inhibitor-induced cytotoxicity by upregulation of extracellular signal-regulated kinase/myeloid leukemia cell-1 signaling.Semantic proximity Read ↗

Mitigative efficacy of the clinical dosage administration of granulocyte colony-stimulating factor and romiplostim in mice with severe acute radiation syndromeSemantic proximity Read ↗

Short-term statin treatment reduces, and long-term statin treatment abolishes chronic vascular injury by radiation therapySemantic proximity Read ↗

Loss of Sirt3 accelerates arterial thrombosis by increasing formation of neutrophil extracellular traps and plasma tissue factor activity.Semantic proximity Read ↗

Mesenchymal Stem Cell Therapy Protects Lungs from Radiation-Induced Endothelial Cell Loss by Restoring Superoxide Dismutase 1 Expression.Semantic proximity Read ↗

Therapeutic administration of recombinant human granulocyte colony‐stimulating factor accelerates hemopoietic regeneration and enhances survival in a murine model of radiation‐induced myelosuppressionSemantic proximity Read ↗

Alpha-tocopherol modulates phosphatidylserine externalization in erythrocytes: relevance in phospholipid transfer protein-deficient mice.Semantic proximity Read ↗

Soluble thrombomodulin protects ischemic kidneys.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.