Article
Medium and large alleles of the PGC gene are risk factors for gastric cancer.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Jan 2023
Sánchez-López Josefina Yoaly, Vázquez-Ibarra Katia Carolina, García-Muro Andrea Marlene, García-Ruvalcaba Azaria, Pacheco-Sotelo Sergio, Díaz-Herrera Luis Carlos, Marin-Contreras Marıa Eugenia
Abstract excerpt
BACKGROUND: A 100-bp insertion/deletion polymorphism in the pepsinogen C gene has been associated with the risk of gastric cancer (GC). OBJECTIVE: We analyzed the relationships of the 100-bp insertion/deletion polymorphism with GC, atrophic gastritis (AG), and intestinal metaplasia (IM) in the Mexican general population (MGP). METHODS: We studied the genomic DNA of subjects with GC n = 80, AG and IM n = 60,...
Topics
- Humans
- Alleles
- Gastritis, Atrophic
- Helicobacter Infections
- Polymorphism, Genetic
- Risk Factors
- Stomach Neoplasms
- Pepsinogen C