Article
Impact of pepsinogen C polymorphism on individual susceptibility to gastric cancer and its precancerous conditions in a Northeast Chinese population.
Journal of cancer research and clinical oncology - 1 Aug 2009
Sun Li-Ping, Guo Xiao-Lin, Zhang Ye, Chen Wei, Bai Xue-Lei, Liu Jin, Yuan Yuan
Abstract excerpt
PURPOSE: Human pepsinogen C (PGC) is an aspartic protease produced specifically by the gastric mucosa, and is considered as a mature marker of gastric epithelium. This study examined the contributions of PGC polymorphisms and the Helicobacter pylori (H. pylori) infection to the risk of gastric cancer (GC), and its precancerous conditions in a Northeast Chinese population. METHODS: The PGC insertion/deletion...
Topics
- Asian People
- Base Sequence
- China
- Enzyme-Linked Immunosorbent Assay
- Gastritis, Atrophic
- Genetic Predisposition to Disease
- Genotype
- Helicobacter Infections
- Helicobacter pylori
- Humans
- Molecular Sequence Data
- Pepsinogen C
- Polymorphism, Genetic