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Article

PGC TagSNP and its interaction with H. pylori and relation with gene expression in susceptibility to gastric carcinogenesis.

PloS one - 1 Jan 2014

He Cai-Yun, Sun Li-Ping, Xu Qian, Liu Jing-Wei, Jiang Jing-Yi, Dong Nan-Nan, Yuan Yuan

Abstract excerpt

BACKGROUND: Pepsinogen C (PGC) plays an important role in sustaining the cellular differentiation during the process of gastric carcinogenesis. This study aimed to assess the role of PGC tagSNPs and their interactions with Helicobacter pylori (H. pylori) in the development of gastric cancer and its precursor, atrophic gastritis. METHODS: Four PGC tagSNPs (rs6941539, rs6912200, rs3789210 and rs6939861) were...

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Topics

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Share to Cell Transformation, Neoplastic
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Share to Genetic Association Studies
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Source

Open in PubMed Open full text

Identifiers

PMID: 25551587
DOI: 10.1371/journal.pone.0115955
PMCID: PMC4281127

Genes

PGC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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