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Article

Repression of ferritin light chain translation by human eIF3

15 Aug 2019

Abstract excerpt

A central problem in human biology remains the discovery of causal molecular links between mutations identified in genome-wide association studies (GWAS) and their corresponding disease traits. This challenge is magnified for variants residing in non-coding regions of the genome. Single-nucleotide polymorphisms (SNPs) in the 5ʹ untranslated region (5ʹ-UTR) of the ferritin light chain ( FTL ) gene that cause...

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PMID: 31414986
DOI: 10.7554/elife.48193

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