Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic susceptibility to severe childhood asthma and rhinovirus-C maintained by balancing selection in humans for 150 000 years.

Human molecular genetics - 27 Mar 2020

O'Neill Mary B, Laval Guillaume, Teixeira João C, Palmenberg Ann C, Pepperell Caitlin S

Abstract excerpt

Selective pressures imposed by pathogens have varied among human populations throughout their evolution, leading to marked inter-population differences at some genes mediating susceptibility to infectious and immune-related diseases. Here, we investigated the evolutionary history of a common polymorphism resulting in a Y529 versus C529 change in the cadherin related family member 3 (CDHR3) receptor which...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asthma
Share to Bayes Theorem

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cadherin Related Proteins

Share to Cadherins

Share to Enterovirus

Share to Genome, Human

Share to History, Ancient

Share to Selection, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 31841129
DOI: 10.1093/hmg/ddz304
PMCID: PMC7104676

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic susceptibility to severe childhood asthma and rhinovirus-C maintained by balancing selection in humans for 150 000 years.PMID 31841129Read ↗

A Complex Evolutionary History for the Disease Susceptibility <i>CDHR3</i> LocusSemantic proximity Read ↗

Cadherin-related Family Member 3 Genetics and Rhinovirus C Respiratory Illnesses.Semantic proximity Read ↗

Genetic impact of CDHR3 on the adult onset of asthma and COPD.Semantic proximity Read ↗

Cadherin-related family member 3, a childhood asthma susceptibility gene product, mediates rhinovirus C binding and replication.Semantic proximity Read ↗

Association between cadherin-related family member 3 rs6967330-A and human rhinovirus-C induced wheezing in childrenSemantic proximity Read ↗

CDHR3 Asthma-Risk Genotype Affects Susceptibility of Airway Epithelium to Rhinovirus C InfectionsSemantic proximity Read ↗

Association of Asthma Risk Alleles With Acute Respiratory Tract Infections and Wheezing Illnesses in Young Children.Semantic proximity Read ↗

Functional genomics of CDHR3 confirms its role in HRV-C infection and childhood asthma exacerbationsSemantic proximity Read ↗

CDHR3 extracellular domains EC1-3 mediate rhinovirus C interaction with cells and as recombinant derivatives, are inhibitory to virus infectionSemantic proximity Read ↗

Genetic association of the functional CDHR3 genotype with early-onset adult asthma in Japanese populations.Semantic proximity Read ↗

Human Rhinovirus Diversity and Evolution: How Strange the Change from Major to MinorSemantic proximity Read ↗

Critically-ill COVID-19 susceptibility gene CCR3 shows natural selection in sub-Saharan Africans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.