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Article

Profiling of actionable gene alterations in ovarian cancer by targeted deep sequencing.

International journal of oncology - 1 Jan 2015

Takenaka Masataka, Saito Motonobu, Iwakawa Reika, Yanaihara Nozomu, Saito Misato, Kato Mamoru, Ichikawa Hitoshi, Shibata Tatsuhiro, Yokota Jun, Okamoto Aikou, Kohno Takashi

Abstract excerpt

To construct a profile of therapeutically actionable gene alterations in the major histological types of ovarian cancer, 72 Japanese patients with surgically resected ovarian cancers were selected from an original cohort consisting of 267 patients who had not received pre-treatment before surgery. Somatic mutations and copy number alterations at 740 hotspots in 46 cancer-related genes were detected by deep...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25846456
DOI: 10.3892/ijo.2015.2951

Genes

AKT1
CTNNB1
ERBB2
KRAS
NRAS
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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