Intratumoral macrophage phenotype and CD8+ T lymphocytes as potential tools to predict local tumor outgrowth at the intervention site in malignant pleural mesothelioma.

doi:10.1016/j.lungcan.2015.03.013

Article

Intratumoral macrophage phenotype and CD8+ T lymphocytes as potential tools to predict local tumor outgrowth at the intervention site in malignant pleural mesothelioma.

Lung cancer (Amsterdam, Netherlands) - 1 Jun 2015

Cornelissen Robin, Lievense Lysanne A, Robertus Jan-Lukas, Hendriks Rudi W, Hoogsteden Henk C, Hegmans Joost P J J, Aerts Joachim G J V

Abstract excerpt

OBJECTIVES: In patients with malignant pleural mesothelioma (MPM), local tumor outgrowth (LTO) after invasive procedures is a well-known complication. Currently, no biomarker is available to predict the occurrence of LTO. This study aims to investigate whether the tumor macrophage infiltration and phenotype of and/or the infiltration of CD8+ T-cells predicts LTO. MATERIALS AND METHODS: Ten mesothelioma patients...

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Intratumoral macrophage phenotype and CD8+ T lymphocytes as potential tools to predict local tumor outgrowth at the intervention site in malignant pleural mesothelioma.

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