[Genome-wide association study as a method for genetic architecture analysis in polygenic diseases (by the example of multiple sclerosis)].

Abstract excerpt

Genome-wide association study (GWAS), which is a powerful tool for investigating the genetic architecture of polygenic disease in humans, is generally applied for identification of genetic factors of disease susceptibility, clinical phenotypes and treatment response. The differences in allele frequencies of genome-wide distributedsingle nucleotide polymorphisms (SNPs) are analyzed with microarray technique or...

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