Article
[The alternative way of colorectal cancer developing. The histogenetic and molecular features of serrated lesions (review, continued)].
Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology - 1 Jan 2014
Ageĭkina N V, Duvanskiĭ V A, Kniazev M V, Mal'kov P G, Danilova N V, Kharlova O A
Abstract excerpt
The occurrence of colorectal cancer can be traced in two ways: from conventional adenomas with the APC-gene mutation (model Fearon-Vogelstein) and the "serrated way", that has a unique genetic profile and morphological characteristics at the early stages. These neoplasms are determined from 7 to 9%. The risk of developing cancer of them is 7.5-15%. Precursors of epithelial neoplasia are aberrant crypts foci....
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