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Article

Type I interferon response is delayed in human astrovirus infections.

PloS one - 1 Jan 2015

Guix Susana, Pérez-Bosque Anna, Miró Lluïsa, Moretó Miquel, Bosch Albert, Pintó Rosa M

Abstract excerpt

Type I interferon (IFN) activation and its subsequent effects are important in the response to viral infections. Here we show that human astroviruses (HAstVs), which are important agents of acute gastroenteritis in children, induce a mild and delayed IFN response upon infecting CaCo-2 cells. Although IFN-β mRNA is detected within infected cells and supernatant from infected cells show antiviral activity against...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25837699
DOI: 10.1371/journal.pone.0123087
PMCID: PMC4383485

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