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OASL Triggered by Novel Goose Astrovirus via ORF2 Restricts Its Replication

22 Sept 2020

Abstract excerpt

Astroviruses cause gastroenteritis and encephalitis in human, and nephritis, hepatitis, and gout disease in poultry. However, the host immune response activated by astrovirus is mostly unknown. Here, we found that a novel goose astrovirus, GAstV-GD, and its ORF2 protein could efficiently induce a high level of OASL in vitro and in vivo, which could feed back to restrict the replication of GAstV-GD, revealing...

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PMID: 32967952
DOI: 10.1128/jvi.01767-20

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