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Article

Duplication of HEY2 in cardiac and neurologic development.

American journal of medical genetics. Part A - 1 Sept 2015

Jordan Valerie K, Rosenfeld Jill A, Lalani Seema R, Scott Daryl A

Abstract excerpt

HEY2 is a basic helix-loop-helix (bHLH) transcription factor that plays an important role in the developing mammalian heart and brain. In humans, nonsynonymous mutations in HEY2 have been described in patients with atrial ventricular septal defects, and a subset of individuals with chromosomal deletions involving HEY2 have cardiac defects and cognitive impairment. Less is known about the potential effects of HEY2...

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Source

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Identifiers

PMID: 25832314
DOI: 10.1002/ajmg.a.37086
PMCID: PMC4545384

Genes

HEY2
GATA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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