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Article

Genetic Variants in Isolated Ebstein Anomaly Implicated in Myocardial Development Pathways.

PloS one - 1 Jan 2016

Sicko Robert J, Browne Marilyn L, Rigler Shannon L, Druschel Charlotte M, Liu Gang, Fan Ruzong, Romitti Paul A, Caggana Michele, Kay Denise M, Brody Lawrence C, Mills James L

Abstract excerpt

Ebstein anomaly (EA) is a rare heart defect in which the tricuspid valve is malformed and displaced. The tricuspid valve abnormalities can lead to backflow of blood from the right ventricle to the right atrium, preventing proper circulation of blood to the lungs. Although the etiology of EA is largely unresolved, increased prevalence of EA in those with a family history of congenital heart disease suggests EA has...

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Identifiers

PMID: 27788187
DOI: 10.1371/journal.pone.0165174
PMCID: PMC5082909

Genes

HEY1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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