Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mitochondrial ATP synthase is dispensable in blood-stage Plasmodium berghei rodent malaria but essential in the mosquito phase.

Proceedings of the National Academy of Sciences of the United States of America - 18 Aug 2015

Sturm Angelika, Mollard Vanessa, Cozijnsen Anton, Goodman Christopher D, McFadden Geoffrey I

Abstract excerpt

Mitochondrial ATP synthase is driven by chemiosmotic oxidation of pyruvate derived from glycolysis. Blood-stage malaria parasites eschew chemiosmosis, instead relying almost solely on glycolysis for their ATP generation, which begs the question of whether mitochondrial ATP synthase is necessary during the blood stage of the parasite life cycle. We knocked out the mitochondrial ATP synthase β subunit gene in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Diphosphate
Share to Culicidae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glycolysis

Share to Luminescent Proteins

Share to Malaria

Share to Mitochondrial Proton-Translocating ATPases

Share to Oocysts

Share to Plasmodium berghei

Source

Open in PubMed Open full text

Identifiers

PMID: 25831536
DOI: 10.1073/pnas.1423959112
PMCID: PMC4547259

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitochondrial ATP synthase is dispensable in blood-stage Plasmodium berghei rodent malaria but essential in the mosquito phase.PMID 25831536Read ↗

Mitochondrial ATP synthesis is essential for efficient gametogenesis in Plasmodium falciparumSemantic proximity Read ↗

Critical roles of the mitochondrial complex II in oocyst formation of rodent malaria parasite Plasmodium berghei.Semantic proximity Read ↗

Mitochondrial ATP synthesis is essential for efficient gametogenesis in <i>Plasmodium falciparum</i>Semantic proximity Read ↗

Life cycle studies of the hexose transporter of Plasmodium species and genetic validation of their essentialitySemantic proximity Read ↗

Identification of cryptic subunits from an apicomplexan ATP synthaseSemantic proximity Read ↗

A genetic screen in rodent malaria parasites identifies five new apicoplast putative membrane transporters, one of which is essential in human malaria parasitesSemantic proximity Read ↗

Malaria parasites utilize pyrophosphate to fuel an essential proton pump in the ring stage and the transition to trophozoite stageSemantic proximity Read ↗

Genetic ablation of the mitoribosome in the malaria parasite Plasmodium falciparum sensitizes it to antimalarials that target mitochondrial functionsSemantic proximity Read ↗

Midgut Mitochondrial Function as a Gatekeeper for Malaria Parasite Infection and Development in the Mosquito HostSemantic proximity Read ↗

Plasmodium falciparum Mitochondrial Complex III, the Target of Atovaquone, Is Essential for Progression to the Transmissible Sexual StagesSemantic proximity Read ↗

Composition and stage dynamics of mitochondrial complexes in Plasmodium falciparumSemantic proximity Read ↗

Copper-transporting ATPase is important for malaria parasite fertility.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.