Article
High-yield production of lipoglycopeptide antibiotic A40926 using a mutant strain Nonomuraea sp. DP-13 in optimized medium.
Preparative biochemistry & biotechnology - 1 Jan 2016
Chen Ming, Xu Tao, Zhang Guanghao, Zhao Jing, Gao Ziqing, Zhang Chunzhi
Abstract excerpt
The lipoglycopeptide antibiotic A40926 produced by Nonomuraea sp. is a complex of structurally related components differing in the fatty acid moiety. Besides showing an intrinsic antibacterial activity, A40926 is the precursor of the semisynthetic antibiotic Dalvance. In this work, A40926 production by a mutant strain Nonomuraea sp. DP-13 was investigated. It was found that A40926 production was markedly promoted...
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