Production and characterization of monochlorinated and dechlorinated A40926 derivatives.

doi:10.7164/antibiotics.56.773

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Article

Production and characterization of monochlorinated and dechlorinated A40926 derivatives.

The Journal of antibiotics - 1 Sept 2003

Beltrametti Fabrizio, Lazzarini Ameriga, Brunati Cristina, Marazzi Alessandra, Jovetic Srdjan, Selva Enrico, Marinelli Flavia

Abstract excerpt

Nonomuraea sp. ATCC 39727 is the producer of the A40926 complex of lipoglycopeptide antibiotics which contain chlorine atoms in amino acids 3 and 6 of the peptide backbone. Using a classical mutagenesis and selection approach we have isolated a Nonomuraea sp. ATCC 39727 mutant strain able to direct production towards new A40926 analogues dechloro-A40926 (DDC) lacking two chlorine atoms and the two...

Topics

Actinomycetales
Anti-Bacterial Agents
Bioreactors
Chlorine
Coagulase
Culture Media
Fermentation
Glycopeptides
Humans
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Molecular Structure
Mutation
Staphylococcus
Teicoplanin

Source

Open in PubMed

Identifiers

PMID: 14632287
DOI: 10.7164/antibiotics.56.773

Genes

DDC
MDC1

Provenance

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