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Article

Key role of ERK pathway signaling in lupus

7 Dec 2009

Abstract excerpt

Systemic lupus erythematosus is a poorly understood autoimmune disease, characterized by autoantibodies to nuclear antigens and immune complex deposition in organs like the kidney. Current evidence indicates that a pathologic CD4+T cell subset, characterized by impaired extracellular signal-regulated kinase (ERK) pathway signaling, DNA hypomethylation, and consequent aberrant gene expression contributes to...

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PMID: 19961364
DOI: 10.3109/08916930903374832

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