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Article

Correction of alternative splicing of tau in frontotemporal dementia and parkinsonism linked to chromosome 17.

The Journal of biological chemistry - 16 Nov 2001

Kalbfuss B, Mabon S A, Misteli T

Abstract excerpt

Mutations in the human tau gene cause frontotemporal dementia and Parkinsonism associated with chromosome 17 (FTDP-17). One of the major disease mechanisms in FTDP-17 is the increased inclusion of tau exon 10 during pre-mRNA splicing. Here we show that modified oligonucleotides directed against the tau exon 10 splice junctions suppress inclusion of tau exon 10. The effect is mediated by the formation of a stable...

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Identifiers

PMID: 11560926
DOI: 10.1074/jbc.M105113200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Correction of alternative splicing of tau in frontotemporal dementia and parkinsonism linked to chromosome 17.PMID 11560926Read ↗

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