Article
Genetically engineered minipigs model the major clinical features of human neurofibromatosis type 1
26 Sept 2018
Abstract excerpt
). NF1 patients present with a variety of clinical manifestations and are predisposed to cancer development. Many NF1 animal models have been developed, yet none display the spectrum of disease seen in patients and the translational impact of these models has been limited. We describe a minipig model that exhibits clinical hallmarks of NF1, including café au lait macules, neurofibromas, and optic pathway glioma....
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