Article
Reappraisal of PLA2R1 in membranous nephropathy: immunostaining method influence and association with IgG4-dominant phenotype.
Virchows Archiv : an international journal of pathology - 1 Jul 2015
Hara Shigeo, Goto Shunsuke, Kamiura Nozomu, Yoshimoto Akihiro, Naito Takayuki, Imagawa Naoko, Imai Yukihiro, Yanagita Motoko, Nishi Shinichi, Itoh Tomoo
Abstract excerpt
The M-type phospholipase A2 receptor (PLA2R1) was identified recently as a specific target antigen in idiopathic membranous nephropathy. However, the influence of different sample preparation techniques on the immunostaining of PLA2R1 is unclear. Previous studies have identified IgG4 as the dominant subclass of PLA2R1 antibodies. However, it remains unclear whether the IgG subclass profiles of the glomerular...
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