Article
Control of Cellular Aging, Tissue Function, and Cancer by p53 Downstream of Telomeres.
Cold Spring Harbor perspectives in medicine - 1 May 2017
Roake Caitlin M, Artandi Steven E
Abstract excerpt
Telomeres, the nucleoprotein complex at the ends of eukaryotic chromosomes, perform an essential cellular role in part by preventing the chromosomal end from initiating a DNA-damage response. This function of telomeres can be compromised as telomeres erode either as a consequence of cell division in culture or as a normal part of cellular ageing in proliferative tissues. Telomere dysfunction in this context leads...
Topics
- Animals
- Apoptosis
- Cell Cycle Checkpoints
- Cellular Senescence
- DNA Damage
- Humans
- Mice
- Mutation
- Neoplasms
- Signal Transduction
- Telomerase
- Telomere