Human IL-32 expression protects mice against a hypervirulent strain of Mycobacterium tuberculosis.

doi:10.1073/pnas.1424302112

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Article

Human IL-32 expression protects mice against a hypervirulent strain of Mycobacterium tuberculosis.

Proceedings of the National Academy of Sciences of the United States of America - 21 Apr 2015

Bai Xiyuan, Shang Shaobin, Henao-Tamayo Marcela, Basaraba Randall J, Ovrutsky Alida R, Matsuda Jennifer L, Takeda Katsuyuki, Chan Mallory M, Dakhama Azzeddine, Kinney William H, Trostel Jessica, Bai An, Honda Jennifer R, Achcar Rosane, Hartney John, Joosten Leo A B, Kim Soo-Hyun, Orme Ian, Dinarello Charles A, Ordway Diane J, Chan Edward D

Abstract excerpt

Silencing of interleukin-32 (IL-32) in a differentiated human promonocytic cell line impairs killing of Mycobacterium tuberculosis (MTB) but the role of IL-32 in vivo against MTB remains unknown. To study the effects of IL-32 in vivo, a transgenic mouse was generated in which the human IL-32γ gene is expressed using the surfactant protein C promoter (SPC-IL-32γTg). Wild-type and SPC-IL-32γTg mice were infected...

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Identifiers

PMID: 25820174
DOI: 10.1073/pnas.1424302112
PMCID: PMC4413346

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