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Article

Polymorphisms of Genes Involved in Glucose and Energy Metabolic Pathways and Prostate Cancer: Interplay with Metformin.

European urology - 1 Dec 2015

Murtola Teemu J, Wahlfors Tiina, Haring Antti, Taari Kimmo, Stenman Ulf-Håkan, Tammela Teuvo L J, Schleutker Johanna, Auvinen Anssi

Abstract excerpt

BACKGROUND: Energy metabolism is important in cancer proliferation and progression, but its role in prostate cancer (PCa) remains unclear. OBJECTIVE: We explored whether single-nucleotide polymorphisms (SNPs) of genes involved in energy metabolic pathways are associated with PCa risk and prognosis, and whether antidiabetic treatment modifies any such association. DESIGN, SETTING, AND PARTICIPANTS: The PRACTICAL...

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PMID: 25819720
DOI: 10.1016/j.eururo.2015.03.026

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