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Article

Performance of an adipokine pathway-based multilocus genetic risk score for prostate cancer risk prediction.

PloS one - 1 Jan 2012

Ribeiro Ricardo J T, Monteiro Cátia P D, Azevedo Andreia S M, Cunha Virgínia F M, Ramanakumar Agnihotram V, Fraga Avelino M, Pina Francisco M, Lopes Carlos M S, Medeiros Rui M, Franco Eduardo L

Abstract excerpt

Few biomarkers are available to predict prostate cancer risk. Single nucleotide polymorphisms (SNPs) tend to have weak individual effects but, in combination, they have stronger predictive value. Adipokine pathways have been implicated in the pathogenesis. We used a candidate pathway approach to investigate 29 functional SNPs in key genes from relevant adipokine pathways in a sample of 1006 men eligible for...

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Identifiers

PMID: 22792137
DOI: 10.1371/journal.pone.0039236
PMCID: PMC3387135

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