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Association between metformin medication, genetic variation and prostate cancer risk.

Prostate cancer and prostatic diseases - 1 Mar 2021

Lee Min Joon, Jayalath Viranda H, Xu Wei, Lu Lin, Freedland Stephen J, Fleshner Neil E, Kulkarni Girish S, Finelli Antonio, van der Kwast Theodorus H, Hamilton Robert J

Abstract excerpt

BACKGROUND: The relationship between metformin use and prostate cancer risk remains controversial. Genetic variation in metformin metabolism pathways appears to modify metformin glycemic control and the protective association with some cancers. However, no studies to date have examined this pharmacogenetic interaction and prostate cancer chemoprevention. METHODS: Clinical data and germline DNA were collected from...

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PMID: 32424261
DOI: 10.1038/s41391-020-0238-y

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