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Article

Dimeric c-di-GMP is required for post-translational regulation of alginate production in Pseudomonas aeruginosa.

The Journal of biological chemistry - 15 May 2015

Whitney John C, Whitfield Gregory B, Marmont Lindsey S, Yip Patrick, Neculai A Mirela, Lobsanov Yuri D, Robinson Howard, Ohman Dennis E, Howell P Lynne

Abstract excerpt

Pseudomonas aeruginosa is an opportunistic human pathogen that secretes the exopolysaccharide alginate during infection of the respiratory tract of individuals afflicted with cystic fibrosis and chronic obstructive pulmonary disease. Among the proteins required for alginate production, Alg44 has been identified as an inner membrane protein whose bis-(3',5')-cyclic dimeric guanosine monophosphate (c-di-GMP)...

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Identifiers

PMID: 25817996
DOI: 10.1074/jbc.M115.645051
PMCID: PMC4432266

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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