Article
Pseudomonas aeruginosa uses a cyclic-di-GMP-regulated adhesin to reinforce the biofilm extracellular matrix.
Molecular microbiology - 1 Feb 2010
Borlee Bradley R, Goldman Aaron D, Murakami Keiji, Samudrala Ram, Wozniak Daniel J, Parsek Matthew R
Abstract excerpt
Pseudomonas aeruginosa, the principal pathogen of cystic fibrosis patients, forms antibiotic-resistant biofilms promoting chronic colonization of the airways. The extracellular (EPS) matrix is a crucial component of biofilms that provides the community multiple benefits. Recent work suggests that the secondary messenger, cyclic-di-GMP, promotes biofilm formation. An analysis of factors specifically expressed in...
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