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Article

Comprehensive transcriptome profiling of BET inhibitor-treated HepG2 cells

29 Apr 2022

Abstract excerpt

Hepatocellular carcinoma (HCC) is the most common primary liver cancer and poor prognosis. Emerging evidence suggests that epigenetic alterations play a crucial role in HCC, suggesting epigenetic inhibition as a promising therapeutic approach. Indeed, the bromodomain and extra-terminal (BET) inhibitors inhibit the proliferation and invasion of various cancers but still lack a strong mechanistic rationale. Here,...

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PMID: 35486664
DOI: 10.1371/journal.pone.0266966

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