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Article

The genetic variants in the PTEN/PI3K/AKT pathway predict susceptibility and CE(A)F chemotherapy response to breast cancer and clinical outcomes.

Oncotarget - 21 Mar 2017

Li Xiang, Zhang Ruishan, Liu Zhuangkai, Li Shuang, Xu Hong

Abstract excerpt

The PI3K/PTEN/AKT pathway play a critical role in balancing cell growth and death. Epidemiologic studies suggested that mutations of the PI3K/PTEN/AKT pathway genes are associated with cancer risk, yet no data are available for PTEN rs701848, PIK3CA rs2699887, and AKT1 rs2494752 polymorphism and breast cancer(BC) risk. A case-control study was performed in 920 BC patients and 908 healthy controls using the TaqMan...

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Share to Antineoplastic Combined Chemotherapy Protocols
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Identifiers

PMID: 28423632
DOI: 10.18632/oncotarget.15690
PMCID: PMC5386760

Genes

PTEN
AKT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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