Article
METTL23 mutation alters histone H3R17 methylation in normal-tension glaucoma.
The Journal of clinical investigation - 1 Nov 2022
Pan Yang, Suga Akiko, Kimura Itaru, Kimura Chojiro, Minegishi Yuriko, Nakayama Mao, Yoshitake Kazutoshi, Iejima Daisuke, Minematsu Naoko, Yamamoto Megumi, Mabuchi Fumihiko, Takamoto Mitsuko, Shiga Yukihiro, Araie Makoto, Kashiwagi Kenji, Aihara Makoto, Nakazawa Toru, Iwata Takeshi
Abstract excerpt
Normal-tension glaucoma (NTG) is a heterogeneous disease characterized by retinal ganglion cell (RGC) death leading to cupping of the optic nerve head and visual field loss at normal intraocular pressure (IOP). The pathogenesis of NTG remains unclear. Here, we describe a single nucleotide mutation in exon 2 of the methyltransferase-like 23 (METTL23) gene identified in 3 generations of a Japanese family with NTG....
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