Article
Cadherin 5 is regulated by corticosteroids and associated with central serous chorioretinopathy.
Human mutation - 1 Jul 2014
Schubert Carl, Pryds Anders, Zeng Shemin, Xie Yajing, Freund K Bailey, Spaide Richard F, Merriam John C, Barbazetto Irene, Slakter Jason S, Chang Stanley, Munch Inger C, Drack Arlene V, Hernandez Jasmine, Yzer Suzanne, Merriam Joanna E, Linneberg Allan, Larsen Michael, Yannuzzi Lawrence A, Mullins Robert F, Allikmets Rando
Abstract excerpt
Central serous chorioretinopathy (CSC) is characterized by leakage of fluid from the choroid into the subretinal space and, consequently, loss of central vision. The disease is triggered by endogenous and exogenous corticosteroid imbalance and psychosocial stress and is much more prevalent in men. We studied the association of genetic variation in 44 genes from stress response and corticosteroid metabolism...
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