Article
Genetic Modifiers of Sickle Cell Disease: A Genotype-Phenotype Relationship Study in a Cohort of 82 Children on Mayotte Island.
Hemoglobin - 1 Jan 2015
Muszlak Mathias, Pissard Serge, Badens Catherine, Chamouine Abdourahim, Maillard Olivier, Thuret Isabelle
Abstract excerpt
Sickle cell disease presents a great clinical variability that remains largely misunderstood. New disease protective genetic modifiers acting mainly through an increased Hb F level have recently been described. We studied relations between clinical and hematological phenotypes and known sickle cell disease genetic modifiers in patients from Mayotte Island, a remote French territory located in the Indian Ocean....
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