Article
Genetic modifiers of sickle cell disease.
Hemoglobin - 1 Jan 2011
Thein Swee Lay
Abstract excerpt
Sickle cell disease is one of the best characterized human monogenic disorders. Complex genotype/phenotype correlations clearly demonstrate the interaction of multiple genetic and environmental factors. In the last 20 years, scientific research has applied genetic approaches to dissect some of these modifiers. This review highlights the more recent genetic association studies that have been applied to unravel the...
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