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Article

Response to methylphenidate in adults with ADHD is associated with a polymorphism in SLC6A3 (DAT1).

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Mar 2008

Kooij J Sandra, Boonstra A Marije, Vermeulen Sita H, Heister Angelien G, Burger Huibert, Buitelaar Jan K, Franke Barbara

Abstract excerpt

In this pharmacogenetic study in adults with ADHD (n = 42), a stratified analysis was performed of the association between response to methylphenidate (MPH), assessed under double-blind conditions, and polymorphisms in the genes encoding the dopamine transporter, SLC6A3 (DAT1), the norepinephrine transporter, SLC6A2 (NET), and the dopamine receptor D4, DRD4. The VNTR polymorphism in the 3' untranslated region of...

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Share to Attention Deficit Disorder with Hyperactivity
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Dopamine Plasma Membrane Transport Proteins

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Source

Identifiers

PMID: 17955457
DOI: 10.1002/ajmg.b.30586

Genes

DRD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Response to methylphenidate in adults with ADHD is associated with a polymorphism in SLC6A3 (DAT1).PMID 17955457Read ↗

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Meta-analysis of the association between dopamine transporter genotype and response to methylphenidate treatment in ADHD.Semantic proximity Read ↗

Response to methylphenidate is not influenced by DAT1 polymorphisms in a sample of Brazilian adult patients with ADHD.Semantic proximity Read ↗

Association analysis of norepinephrine transporter polymorphisms and methylphenidate response in ADHD patients.Semantic proximity Read ↗

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DRD4 exon 3 genotype and ADHD: Randomised pharmacodynamic investigation of treatment response to methylphenidate.Semantic proximity Read ↗

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