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Article

Paired analysis of TCRα and TCRβ chains at the single-cell level in mice.

The Journal of clinical investigation - 1 Jan 2011

Dash Pradyot, McClaren Jennifer L, Oguin Thomas H, Rothwell William, Todd Brandon, Morris Melissa Y, Becksfort Jared, Reynolds Cory, Brown Scott A, Doherty Peter C, Thomas Paul G

Abstract excerpt

Characterizing the TCRα and TCRβ chains expressed by T cells responding to a given pathogen or underlying autoimmunity helps in the development of vaccines and immunotherapies, respectively. However, our understanding of complementary TCRα and TCRβ chain utilization is very limited for pathogen- and autoantigen-induced immunity. To address this problem, we have developed a multiplex nested RT-PCR method for the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21135507
DOI: 10.1172/JCI44752
PMCID: PMC3007160

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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