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Article

Superoxide dismutase 1 encoding mutations linked to ALS adopts a spectrum of misfolded states.

Molecular neurodegeneration - 17 Nov 2011

Prudencio Mercedes, Borchelt David R

Abstract excerpt

BACKGROUND: Mutations in superoxide dismutase 1 (SOD1), which are one cause of familial amyotrophic lateral sclerosis (fALS), induce misfolding and aggregation of the protein. Misfolding can be detected by the binding of antibodies raised against peptide epitopes that are normally buried in the native conformation, shifts in solubility in non-ionic detergents, and the formation of macromolecular inclusions. In...

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Identifiers

PMID: 22094223
DOI: 10.1186/1750-1326-6-77
PMCID: PMC3248846

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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