Article
Genome-wide association study in an admixed case series reveals IL12A as a new candidate in Behçet disease.
PloS one - 1 Jan 2015
Kappen Jasper H, Medina-Gomez Carolina, van Hagen P Martin, Stolk Lisette, Estrada Karol, Rivadeneira Fernando, Uitterlinden Andre G, Stanford Miles R, Ben-Chetrit Eldat, Wallace Graham R, Soylu Merih, van Laar Jan A M
Abstract excerpt
INTRODUCTION: The etiology of Behçet's disease (BD) is unknown, but widely considered an excessive T-cell mediated inflammatory response in a genetically susceptible host. Recent genome-wide association studies (GWAS) have shown limited number of novel loci-associations. The rarity and unequal distribution of the disease prevalence amongst different ethnic backgrounds have hampered the use of GWAS in cohorts of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.