Article
Dense genotyping of immune-related loci implicates host responses to microbial exposure in Behçet's disease susceptibility.
Nature genetics - 1 Mar 2017
Takeuchi Masaki, Mizuki Nobuhisa, Meguro Akira, Ombrello Michael J, Kirino Yohei, Satorius Colleen, Le Julie, Blake Mary, Erer Burak, Kawagoe Tatsukata, Ustek Duran, Tugal-Tutkun Ilknur, Seyahi Emire, Ozyazgan Yilmaz, Sousa Inês, Davatchi Fereydoun, Francisco Vânia, Shahram Farhad, Abdollahi Bahar Sadeghi, Nadji Abdolhadi, Shafiee Niloofar Mojarad, Ghaderibarmi Fahmida, Ohno Shigeaki, Ueda Atsuhisa, Ishigatsubo Yoshiaki, Gadina Massimo, Oliveira Sofia A, Gül Ahmet, Kastner Daniel L, Remmers Elaine F
Abstract excerpt
We analyzed 1,900 Turkish Behçet's disease cases and 1,779 controls genotyped with the Immunochip. The most significantly associated SNP was rs1050502, a tag SNP for HLA-B*51. In the Turkish discovery set, we identified three new risk loci, IL1A-IL1B, IRF8, and CEBPB-PTPN1, with genome-wide significance (P < 5 × 10-8) by direct genotyping and ADO-EGR2 by imputation. We replicated the ADO-EGR2, IRF8, and...
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