Article
Genetics of Behçet disease inside and outside the MHC.
Annals of the rheumatic diseases - 1 Apr 2010
Meguro Akira, Inoko Hidetoshi, Ota Masao, Katsuyama Yoshihiko, Oka Akira, Okada Eiichi, Yamakawa Ryoji, Yuasa Takenosuke, Fujioka Toshihiko, Ohno Shigeaki, Bahram Seiamak, Mizuki Nobuhisa
Abstract excerpt
BACKGROUND: Behçet disease (BD) is a rare, chronic, systemic, inflammatory disorder characterised by recurrent ocular, genital and skin lesions. Although its aetiology is still uncertain, an intricate interplay between the environment (eg, viruses) and the host seems to initiate and/or perpetuate the disease, although the mechanism remains speculative. Since the identification of HLA-B*5101 (and more recently of...
Topics
- Behcet Syndrome
- Case-Control Studies
- Gene Frequency
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Genotype
- HLA-A Antigens
- HLA-B Antigens
- Haplotypes
- Histocompatibility Testing