Article
Apical spectrin organizes cortical actin filament bundles to pattern C. elegans cuticle ridges.
PLoS genetics - 1 Jul 2026
Sarwar Prioty Ferheen, Barker Trevor James, Nguyen Ken, Chan Fung-Yi, Hall David H, Carvalho Ana Xavier, Sundaram Meera Vedavalli
Abstract excerpt
The apical extracellular matrix can form elaborate three-dimensional structures on animal surfaces. To better understand the mechanisms that pattern and shape these structures, we focus on development of collagen-rich cuticle ridges (alae) in adult C. elegans. Previous studies suggested that longitudinal actin filament bundles (AFBs) in the lateral seam epidermis specify alae position through a mechanism that...
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