Article
S-nitrosoglutathione reductase-dependent PPARγ denitrosylation participates in MSC-derived adipogenesis and osteogenesis.
The Journal of clinical investigation - 1 Apr 2015
Cao Yenong, Gomes Samirah A, Rangel Erika B, Paulino Ellena C, Fonseca Tatiana L, Li Jinliang, Teixeira Marilia B, Gouveia Cecilia H, Bianco Antonio C, Kapiloff Michael S, Balkan Wayne, Hare Joshua M
Abstract excerpt
Bone marrow-derived mesenchymal stem cells (MSCs) are a common precursor of both adipocytes and osteoblasts. While it is appreciated that PPARγ regulates the balance between adipogenesis and osteogenesis, the roles of additional regulators of this process remain controversial. Here, we show that MSCs isolated from mice lacking S-nitrosoglutathione reductase, a denitrosylase that regulates protein S-nitrosylation,...
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