Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PPAR-γ and Wnt Regulate the Differentiation of MSCs into Adipocytes and Osteoblasts Respectively

17 Oct 2017

Abstract excerpt

BACKGROUND: Under the transcriptional control of numerous factors and intracellular signals, mesenchymal stem cells (MSCs) can differentiate into various cell types, including adipocytes and osteoblasts. However, the precise cellular signaling factors that determine the cell fate of MSCs in bone marrow remain largely unknown. OBJECTIVE: In this review, we focus on the ties of PPAR-γ and Wnt signaling in MSC...

Topics

Join the communities discussing this publication.

Mesenchymal stem cell research
Peroxisome Proliferator-Activated Receptors
Wnt/β-catenin signaling in development and cancer

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 29034841
DOI: 10.2174/1574888x12666171012141908

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PPAR-γ and Wnt Regulate the Differentiation of MSCs into Adipocytes and Osteoblasts RespectivelyPMID 29034841Read ↗

PPARγ; and Wnt Signaling in Adipogenic and Osteogenic Differentiation of Mesenchymal Stem CellsSemantic proximity Read ↗

Review of Signaling Pathways Governing MSC Osteogenic and Adipogenic DifferentiationSemantic proximity Read ↗

Fate decision of mesenchymal stem cells: adipocytes or osteoblasts?Semantic proximity Read ↗

A New Concept Underlying Stem Cell Lineage Skewing That Explains the Detrimental Effects of Thiazolidinediones on BoneSemantic proximity Read ↗

A Comprehensive Analysis of the Dual Roles of BMPs in Regulating Adipogenic and Osteogenic Differentiation of Mesenchymal Progenitor CellsSemantic proximity Read ↗

PPARγ suppression inhibits adipogenesis but does not promote osteogenesis of human mesenchymal stem cellsSemantic proximity Read ↗

β-catenin directly sequesters adipocytic and insulin sensitizing activities but not osteoblastic activity of PPARγ2 in marrow mesenchymal stem cells.Semantic proximity Read ↗

How mesenchymal stem cells transform into adipocytes: Overview of the current understanding of adipogenic differentiationSemantic proximity Read ↗

Controlling the balance between osteoblastogenesis and adipogenesis and the consequent therapeutic implicationsSemantic proximity Read ↗

PPARβ/δ governs Wnt signaling and bone turnover.Semantic proximity Read ↗

Adipogenesis: A Complex Interplay of Multiple Molecular Determinants and PathwaysSemantic proximity Read ↗

Ectopic overexpression of adipogenic transcription factors induces transdifferentiation of MC3T3-E1 osteoblasts.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.