Article
Impact of amino acid substitutions in the V2 and C2 regions of human immunodeficiency virus type 1 CRF01_AE envelope glycoprotein gp120 on viral neutralization susceptibility to broadly neutralizing antibodies specific for the CD4 binding site.
Retrovirology - 23 Apr 2014
Utachee Piraporn, Isarangkura-na-ayuthaya Panasda, Tokunaga Kenzo, Ikuta Kazuyoshi, Takeda Naokazu, Kameoka Masanori
Abstract excerpt
BACKGROUND: The CD4 binding site (CD4bs) of envelope glycoprotein (Env) gp120 is a functionally conserved, important target of anti-human immunodeficiency virus type 1 (HIV-1) neutralizing antibodies. Two neutralizing human monoclonal antibodies, IgG1 b12 (b12) and VRC01, are broadly reactive neutralizing antibodies which recognize conformational epitopes that overlap the CD4bs of Env gp120; however, many...
Topics
- Amino Acid Substitution
- Antibodies, Neutralizing
- Asia, Southeastern
- Binding Sites
- CD4-Positive T-Lymphocytes
- Genotype
- HIV Antibodies
- HIV Envelope Protein gp120
- HIV Infections
- HIV-1
- Humans
- Mutant Proteins