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Article

A single residue within the V5 region of HIV-1 envelope facilitates viral escape from the broadly neutralizing monoclonal antibody VRC01.

The Journal of biological chemistry - 14 Dec 2012

Guo Dongxing, Shi Xuanling, Arledge Kelly C, Song Dingka, Jiang Liwei, Fu Lili, Gong Xinqi, Zhang Senyan, Wang Xinquan, Zhang Linqi

Abstract excerpt

VRC01, a broadly neutralizing monoclonal antibody, is capable of neutralizing a diverse array of HIV-1 isolates by mimicking CD4 binding with the envelope glycoprotein gp120. Nonetheless, resistant strains have been identified. Here, we examined two genetically related and two unrelated envelope clones, derived from CRF08_BC-infected patients, with distinct VRC01 neutralization profiles. A total of 22 chimeric...

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Identifiers

PMID: 23100255
DOI: 10.1074/jbc.M112.399402
PMCID: PMC3522310

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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