Identification of an HIV-1 clade A envelope that exhibits broad antigenicity and neutralization sensitivity and elicits antibodies targeting three distinct epitopes.

doi:10.1128/JVI.02827-12

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Article

Identification of an HIV-1 clade A envelope that exhibits broad antigenicity and neutralization sensitivity and elicits antibodies targeting three distinct epitopes.

Journal of virology - 1 May 2013

Hoffenberg Simon, Powell Rebecca, Carpov Alexei, Wagner Denise, Wilson Aaron, Kosakovsky Pond Sergei, Lindsay Ross, Arendt Heather, Destefano Joanne, Phogat Sanjay, Poignard Pascal, Fling Steven P, Simek Melissa, Labranche Celia, Montefiori David, Wrin Terri, Phung Pham, Burton Dennis, Koff Wayne, King C Richter, Parks Christopher L, Caulfield Michael J

Abstract excerpt

Broadly neutralizing antibodies (bNAbs) PG9 and PG16 were isolated from an International AIDS Vaccine Initiative (IAVI) Protocol G subject infected with human immunodeficiency virus type 1 (HIV-1) clade A. Both antibodies are highly potent and neutralize greater than 70% of viruses tested. We sought to begin immunogen design based on viral sequences from this patient; however, pseudoviruses prepared with 19...

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PMID: 23468492
DOI: 10.1128/JVI.02827-12
PMCID: PMC3648150

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