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Article

The CYP19 RS4646 polymorphism IS related to the prognosis of stage I-II and operable stage III breast cancer.

PloS one - 1 Jan 2015

Shao Xiying, Guo Yong, Xu Xiaohong, Zheng Yabing, Wang Jiwen, Chen Zhanhong, Huang Jian, Huang Ping, Cai Jufen, Wang Xiaojia

Abstract excerpt

PURPOSE: Aromatase, encoded by the CYP19 gene, catalyzes the final step of the conversion of androgens to estrogens. Given the critical role of CYP19 in estrogen synthesis, the potential influence of CYP19 rs4646 polymorphism on breast cancer survival, deserves further study. METHODS: Genotyping for CYP19 rs4646 variants was performed on 406 Chinese women with stage I-II and operable stage III breast cancer....

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PMID: 25793413
DOI: 10.1371/journal.pone.0121535
PMCID: PMC4368615

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